If it was just the werewolf in question and the open road, I'm sure (s)he would be fine. But otherwise, I'm sure the changes would cause a serious distraction and as we all know from taking drivers ed (You did take drivers education right?) "It only takes one second to create chaos with your vehicle"
If I was a werewolf myself and by surprise I didn't check my calender and all that and I'd be changing in the car, I'm sure that I could still drive. I'd just make sure that...
A) My height allows me to see the road. If I was in wolf form instead of gesalt, I'd be quite worried that my head wouldn't make it past the dash board.
B) I'd steer the car not by using the ring part of the steering wheel, but by pushing the inner part around in a circular motion. That would allow me to drive without thumbs.
C) I just don't scare the cop for pulling me over thinking that I was driving with distractive gear on only to realize...

<8^0-"AHHHHH!!!! He's not fursuiting!!!!"
But honestly.Why would I drive a car while shifted? It's not like werwolves have our kind of bum in their shifted state. Not only would a tail be a nusaince in a car, but their bum would hurt like bejesus after sitting like us for a few minutes. And where the hind legs are concerned, The hock might actually have to touch the ground to operate on the gas and break pedals. What a shame that would be to your newly shifted feet.
Would I really be driving to some place in my own car after I shifted? Nope. I do something like this...
*looks up at the sky*
Dang It's the full moon and I'm changing. How am I ever going to that 1 o'clock business meeting without driving like a fool through downtown NYC?
I Know! I'll take a taxi!
"Hey Taxi...TAXI..."